The idea is to link IP3 calcium induced oscillations to acto-myosin contractility. I think there is a link between the tension of the cortical actin and calcium signaling. In short:

1. At the equilibrium state actin binds to myosin at a given ratio and at a specified rate giving rise to Acto-myosin polymer. If the concentration of Acto-myosin polymer is at a suboptimal concentration, calcium is released by ER through IP3 pathway.

2. High concentration of calcium in the cytoplasm leads to Acto-myosin polymer depolymerization, cycle repeats until the equilibrium between actin and myosin is reached.

I would be more than happy if someone would like to join to this project.




One response to “Jakub_Sedzinski_and_Mr._Ryan_Waters_Project_legendary_Idea

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