Nima Sharifai, Project Idea

To link a specific protein-protein interaction (Cdc42 and WASp) via FRET efficiency values over a spatial domain (x) to dendritic/axonal membrane protrusion (delta x). Actin polymerization rate, which is dependent on WASp activation, may also be modeled as the mediator of FRET efficiency–>membrane protrusion.

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