Project Idea – Incoherente Feedforward loop for cell cycle reentry – Alicia Grande [Harris]

I am interested in understanding what are the mechanisms involved in the cell cycle reentry when yeast cells are under low doses of pheromone. My hypothesis is that the pheromone triggers not only the activation of the pheromone pathway but also with a delay, the increase of Cln3 (cyclin of G1). Therefore, I am going to implement the incoherent feedforward loop and see if I can explain my data only with this motif.

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