Project Idea: Mathematical model of autophagy activation pathway – Eric Yang [Jalil]

Autophagy is a highly orchestrated degradative process that sequesters and degrades damaged or excess organelles in response to internal and external stress including starvation, oxygen limitation, microbial invasion and hormonal stimulation. The understanding of biochemical pathway of autophagy is important in determining the fate of cells that respond to stress including the challenge of chemotherapeutic agents. This project will build a mathematical model for the activation of autophagy by nutrient deprivation (low concentration of amino acids) with feedback loop when the amino acids generated by protein degradation increases the amino acid pool. I am especially interested in how the amino acid level affects the activation of autophagy and how the feedback parameter (due to autophagic degradation of protein) influences the concentration of total amino acid.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s