Project Idea: Noisy gene expression resulting from G-Quadruplexes – Bharat Ravi [Weinberg]

G-quadrulexes are nucleic acid super-secondary structures formed by four strands (intra/intermolecular). The Guanines in the different strands interact by Hoogsteen type hydrogen bonding.  G-quadruplexes forming sequences are found in geneic regions and experiments using immunoprecipitations have validated this prediction. These DNA regions can alternate between quadruplex and duplex structures. Quadruplex structure can impede the elongation of transcription. I aim to use stochastic modeling to predict if quadruplexes can give rise to gene expression noise. Improvisations in the model will include studying transcription bursts and studying the effect of RNA quadruplexes in the translation process.


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