Project Idea: The circadian rhythm and its robustness – Wai Shing Lee [Jalil]

I plan to study some previous models on the study of circadian rhythms based on modeling of gene-protein interactions. Other than studying the possible behaviors of such models, what has been most interesting to me for this class of problems is the robustness requirements imposed on such models. For instance, while the rate constants of chemical reactions are generally temperature dependent, our biological clocks nevertheless exhibit very similar rhythm in both winter and summer. Thus, it is an interesting question on how such robustness can actually come up, and what biological structural characteristics may be responsible for it. While there seems to be many different proposals in the market, it is an background question that I would like to look deeper as well.


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