Author Archives: myf1919

Marc Fink, Student Project Idea

I am going to develop a model of acute resistance to the HER2 inhibitor, lapatinib, in breast cancer cells.  Upon inhibition of HER2 activity, cells up-regulate the levels of several receptor tyrosine kinases.  These RTKs promote survival signaling.  These events will be modeled and this will be used to explain resistance.